Netzloff M L
Ann Clin Lab Sci. 1979 Jul-Aug;9(4):263-7.
The occurrence of vaginal clear cell adenocarcinoma in young women following exposure in utero to diethylstilbestrol (DES) is now well documented. In addition to this carcinogenic potential. DES has been shown to be teratogenic. In females, the DES-related malformations include vaginal adenosis, transverse ridges of the vagina or cervix and uterine abnormalities. Although no neoplasms have been observed in DES-exposed males, malformations of the epididymis, testes and phallus are relatively common and may result in infertility. The carcinogenic mechanism of DES may be either a direct induction of malignant potential in vaginal cells or a teratogenic effect causing ectopic Müllerian epithelium which could be exposed later to mutagenic agents in the vagina. The absence of malignancy in DES-exposed males may favor the latter hypothesis since male Müllerian remnants are internal structures and thus would not be exposed to surface carcinogens.
现已充分证明，年轻女性在子宫内接触己烯雌酚（DES）后会发生阴道透明细胞腺癌。除了这种致癌潜力外，DES还被证明具有致畸性。在女性中，与DES相关的畸形包括阴道腺病、阴道或宫颈横嵴以及子宫异常。虽然在接触DES的男性中未观察到肿瘤，但附睾、睾丸和阴茎的畸形相对常见，可能导致不育。DES的致癌机制可能是直接诱导阴道细胞的恶性潜能，或者是致畸作用导致异位苗勒上皮，后者随后可能接触到阴道中的诱变剂。接触DES的男性中无恶性肿瘤可能支持后一种假设，因为男性苗勒残余物是内部结构，因此不会接触到表面致癌物。
