Garsheva G B, Vasil'ev V K, Grakovskaia L K
Antibiotiki. 1979 Aug;24(8):609-11.
The rate of ampicillin transfer into solution from suspensions of 2 types, i.e. suspensions of anhydrous ampicillin and suspensions of ampicillin trihydrate was studied. Conditions for estimation of the rate of ampicillin dissolution from the suspensions were developed. The pharmacokinetics of the pharmaceutical forms was studied on dogs. Definite advantages of the anhydrous ampicillin suspension were shown as compared to the ampicillin trihydrate suspension.
研究了两种类型的悬浮液中氨苄西林向溶液中的转移速率，即无水氨苄西林悬浮液和三水合氨苄西林悬浮液。制定了评估氨苄西林从悬浮液中溶解速率的条件。在狗身上研究了这些药物剂型的药代动力学。结果表明，与三水合氨苄西林悬浮液相比，无水氨苄西林悬浮液具有一定优势。
