Patt D J, Cohen E P
Immunology. 1974 Mar;26(3):639-47.
RNA synthesis was investigated in the thymus glands of adult immunized mice. After the intraperitoneal injection of mice with sheep red blood cells (SRBC), the net synthesis of RNA in the gland increased. A small but consistent amount of the RNA synthesized was distinguished by RNA:DNA hybridizations from that found in the glands of mice not injected with antigen. The RNA formed after immunization did not appear by hybridization to be specific for different antigens since the species of RNA formed in the glands of mice injected with SRBC was indistinguishable from RNA formed in the thymuses of mice injected with chicken red blood cells. RNA synthesized in the thymus glands of mice pharmacologically `stressed' by the injections of hydrocortisone, however, was distinguishable from that formed in the glands of mice injected with antigen.
对成年免疫小鼠的胸腺中的RNA合成进行了研究。给小鼠腹腔注射绵羊红细胞（SRBC）后，胸腺中RNA的净合成增加。通过RNA:DNA杂交发现，合成的RNA中有一小部分且量较为稳定，与未注射抗原的小鼠胸腺中的RNA不同。免疫后形成的RNA通过杂交显示对不同抗原不具有特异性，因为注射SRBC的小鼠胸腺中形成的RNA种类与注射鸡红细胞的小鼠胸腺中形成的RNA无法区分。然而，通过注射氢化可的松进行药理学“应激”的小鼠胸腺中合成的RNA，与注射抗原的小鼠胸腺中形成的RNA是有区别的。
