血管加压素对离体灌注大鼠肾脏血管系统的影响。
The effect of vasopressin upon the vasculature of the isolated perfused rat kidney.
作者信息
Cross R B, Trace J W, Vattuone J R
出版信息
J Physiol. 1974 Jun;239(3):435-42. doi: 10.1113/jphysiol.1974.sp010576.
Abstract
The timed uptake of (131)I-labelled human serum albumin was used as an index of regional perfusion in the isolated rat kidney.1. Arginine vasopressin in doses of 1, 5 and 10 muu./ml. of perfusate decreased papillary perfusion. Total renal perfusion was decreased only by the 5 muu. dose.2. Ornithine-8-vasopressin in doses of 5 and 10 muu./ml. of perfusate decreased papillary perfusion. Total renal perfusion was decreased only by the 10 muu. dose.3. When the relative viscosity of the perfusate was increased to a value of 2.0 from the control value of 1.7, both papillary perfusion and total renal perfusion were reduced.4. Arginine vasopressin further reduced papillary flow in kidneys perfused with high viscosity artificial plasma.
摘要
用¹³¹I标记的人血清白蛋白的定时摄取作为离体大鼠肾脏局部灌注的指标。1. 灌注液中剂量为1、5和10微单位/毫升的精氨酸加压素可降低乳头灌注。仅5微单位的剂量可降低总肾灌注。2. 灌注液中剂量为5和10微单位/毫升的鸟氨酸-8-加压素可降低乳头灌注。仅10微单位的剂量可降低总肾灌注。3. 当灌注液的相对粘度从对照值1.7增加到2.0时，乳头灌注和总肾灌注均降低。4. 精氨酸加压素可进一步降低用高粘度人工血浆灌注的肾脏的乳头血流。
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