Emperaire J C, Riviere J, Ruffie A, Audebert A J
Arch Androl. 1979 May;2(3):223-31. doi: 10.3109/01485017908987317.
Clomiphene citrate, 50 mg/day, was administered to 105 patients with idiopathic azoospermia or oligoasthenospermia. Plasma FSH, LH, testosterone, and in a few cases estradiol were evaluated on day 0 and day 15 of therapy. Twelve other patients with no treatment were assayed in the same way. Statistical analysis demonstrated that, as a group, the infertile male population responds normally to clomiphene administration. On the other hand, three types of individual responses were recorded: complete positive response, dissociated positive response, and negative response. Sixty-nine patients were randomly selected for clomiphene therapy, 50 mg/day for 100 days; however, of 54 who completed the treatment schedule, only 11 showed elevated sperm counts. A study of correlations between hormonal and semen responses to clomiphene indicates that a complete or dissociated endocrine response is not an accurate predictor of possible semen amelioration on long-term therapy; on the other hand, sperm characteristics did not improve in those patients who did not demonstrate a positive hormonal response, mainly testosterone, on the 15th day of therapy.
对105例特发性无精子症或少弱精子症患者给予枸橼酸氯米芬，剂量为50毫克/天。在治疗的第0天和第15天评估血浆促卵泡生成素（FSH）、促黄体生成素（LH）、睾酮，少数病例评估雌二醇。另外12例未接受治疗的患者也采用相同方法进行检测。统计分析表明，作为一个群体，不育男性群体对氯米芬给药反应正常。另一方面，记录了三种个体反应类型：完全阳性反应、分离阳性反应和阴性反应。随机选择69例患者接受氯米芬治疗，50毫克/天，共100天；然而，在完成治疗方案的54例患者中，只有11例精子计数升高。对氯米芬激素反应与精液反应之间相关性的研究表明，完全或分离的内分泌反应并非长期治疗中精液改善可能性的准确预测指标；另一方面，在治疗第15天未表现出阳性激素反应（主要是睾酮）的患者中，精子特征并未改善。
