Jhamandas K, Sutak M
Br J Pharmacol. 1974 Jan;50(1):57-62. doi: 10.1111/j.1476-5381.1974.tb09592.x.
1 The spontaneous release of acetylcholine (ACh) from the cerebral cortex of control and morphine-dependent rats was investigated. The rate of resting output of ACh in morphine-dependent animals was lower than that in the control animals.2 Administration of naloxone and nalorphine to morphine-dependent rats was followed by a significant rise in the release of cortical ACh. In control rats no such increase in the release of ACh occurred after similar injections of narcotic antagonists.3 Injections of morphine produced a consistent decrease in the rate of spontaneous release of cortical ACh in the control rats, but similar injections in the dependent rats did not produce a decrease in the rate of cortical ACh release.4 The relevance of these results with regard to development of the narcotic abstinence syndrome is discussed.
研究了对照大鼠和吗啡依赖大鼠大脑皮层乙酰胆碱（ACh）的自发释放情况。吗啡依赖动物中ACh的静息输出率低于对照动物。
给吗啡依赖大鼠注射纳洛酮和烯丙吗啡后，皮层ACh的释放显著增加。在对照大鼠中，注射类似的麻醉拮抗剂后，ACh的释放没有出现这种增加。
给对照大鼠注射吗啡会使皮层ACh的自发释放率持续下降，但给依赖大鼠注射类似剂量的吗啡并不会使皮层ACh的释放率下降。
讨论了这些结果与麻醉戒断综合征发展的相关性。
