吗啡戒断期间，皮质乙酰胆碱释放增加，γ-氨基丁酸外流减少。
Cortical acetylcholine release is increased and gamma-aminobutyric acid outflow is reduced during morphine withdrawal.
作者信息
Antonelli T, Beani L, Bianchi C, Rando S, Simonato M, Tanganelli S
出版信息
Br J Pharmacol. 1986 Dec;89(4):853-60. doi: 10.1111/j.1476-5381.1986.tb11191.x.
Abstract
The effects of naloxone on acetylcholine (ACh) and gamma-aminobutyric acid (GABA) outflow from the cerebral cortex of freely moving, morphine-dependent guinea-pigs was studied. The cortical efflux of ACh in chronically-treated guinea-pigs was about half of that of normal animals. GABA efflux was unaffected. During opioid withdrawal precipitated by naloxone (0.1-10 mg kg-1, i.p.) the guinea-pigs showed jumping, hyperactivity and wet dog shakes, the intensity of which was directly related to the dose of naloxone. The withdrawal syndrome was accompanied by a dose-dependent increase in ACh release and reduction in GABA outflow; ACh release was increased by naloxone at doses lower (0.1-3 mg kg-1) than those acting on GABA efflux (1-10 mg kg-1). Atropine (10 mg kg-1) and diazepam (5 mg kg-1) did not prevent GABA and ACh changes.
摘要
研究了纳洛酮对自由活动的吗啡依赖豚鼠大脑皮质乙酰胆碱（ACh）和γ-氨基丁酸（GABA）释放的影响。长期接受治疗的豚鼠皮质ACh流出量约为正常动物的一半。GABA流出量未受影响。在用纳洛酮（0.1 - 10 mg kg-1，腹腔注射）诱发阿片类物质戒断期间，豚鼠表现出跳跃、多动和湿狗样抖动，其强度与纳洛酮剂量直接相关。戒断综合征伴有ACh释放剂量依赖性增加和GABA流出量减少；纳洛酮在低于作用于GABA流出量的剂量（0.1 - 3 mg kg-1）时即可增加ACh释放，而作用于GABA流出量的剂量为（1 - 10 mg kg-1）。阿托品（10 mg kg-1）和地西泮（5 mg kg-1）不能阻止GABA和ACh的变化。
相似文献
1
Cortical acetylcholine release is increased and gamma-aminobutyric acid outflow is reduced during morphine withdrawal.吗啡戒断期间，皮质乙酰胆碱释放增加，γ-氨基丁酸外流减少。
Br J Pharmacol. 1986 Dec;89(4):853-60. doi: 10.1111/j.1476-5381.1986.tb11191.x.
2
Changes in cortical acetylcholine and gamma-aminobutyric acid outflow during morphine withdrawal involve alpha-1 and alpha-2 receptors.吗啡戒断期间皮质乙酰胆碱和γ-氨基丁酸外流的变化涉及α-1和α-2受体。
J Pharmacol Exp Ther. 1989 Aug;250(2):682-7.
3
Diazepam pretreatment suppresses morphine withdrawal signs in the mouse.地西泮预处理可抑制小鼠的吗啡戒断症状。
Life Sci. 1996;58(4):349-57. doi: 10.1016/0024-3205(95)02294-5.
4
Changes in [3H]-UK 14304 binding to alpha 2-adrenoceptors in morphine-dependent guinea-pigs.吗啡依赖豚鼠中[3H]-UK 14304与α2-肾上腺素能受体结合的变化
Br J Pharmacol. 1995 Dec;116(8):3125-32. doi: 10.1111/j.1476-5381.1995.tb15114.x.
5
micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal.μ-阿片受体内化可防止纳洛酮诱发的吗啡戒断过程中腹侧被盖区 GABA 传递的适应。
J Neurosci. 2010 Mar 3;30(9):3276-86. doi: 10.1523/JNEUROSCI.4634-09.2010.
6
7
The modulation of cortical acetylcholine release by GABA, GABA-like drugs and benzodiazepines in freely moving guinea-pigs.在自由活动的豚鼠中，γ-氨基丁酸、类γ-氨基丁酸药物及苯二氮䓬类药物对皮质乙酰胆碱释放的调节作用
Neuropharmacology. 1985 Apr;24(4):291-9. doi: 10.1016/0028-3908(85)90134-0.
8
Effect of acute and subchronic nicotine treatment on cortical efflux of [3H]-D-aspartate and endogenous GABA in freely moving guinea-pigs.急性和亚慢性尼古丁处理对自由活动豚鼠皮质[3H]-D-天冬氨酸和内源性GABA外流的影响。
Br J Pharmacol. 1991 Sep;104(1):15-20. doi: 10.1111/j.1476-5381.1991.tb12377.x.
9
Microdialysis evidence that acetylcholine in the nucleus accumbens is involved in morphine withdrawal and its treatment with clonidine.微透析证据表明伏隔核中的乙酰胆碱参与吗啡戒断反应及其可乐定治疗。
Brain Res. 1991 Oct 11;561(2):354-6. doi: 10.1016/0006-8993(91)91616-9.
10
The effect of naloxone on opioid-induced inhibition and facilitation of acetylcholine release in brain slices.纳洛酮对阿片类药物诱导的脑片乙酰胆碱释放抑制和促进作用的影响。
Br J Pharmacol. 1982 Jul;76(3):393-401. doi: 10.1111/j.1476-5381.1982.tb09233.x.
引用本文的文献
1
MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats.由单纯疱疹病毒载体介导的中脑导水管周围灰质中的锰超氧化物歧化酶可抑制大鼠的吗啡戒断反应。
Gene Ther. 2017 May;24(5):314-324. doi: 10.1038/gt.2017.22. Epub 2017 Apr 3.
2
Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice.曼陀罗树提取物及其次生代谢物对小鼠吗啡耐受和依赖的影响。
Evid Based Complement Alternat Med. 2012;2012:741925. doi: 10.1155/2012/741925. Epub 2012 Feb 8.
3
Changes in acetylcholinesterase activity and muscarinic receptor bindings in mu-opioid receptor knockout mice.μ-阿片受体基因敲除小鼠中乙酰胆碱酯酶活性和毒蕈碱受体结合的变化。
Brain Res Mol Brain Res. 2004 Jul 5;126(1):38-44. doi: 10.1016/j.molbrainres.2004.03.011.
4
The bindings of [3H]muscimol and [3H]flunitrazapam are elevated in discrete brain regions of butorphanol-withdrawal rats.在布托啡诺戒断大鼠的特定脑区中，[3H]蝇蕈醇和[3H]氟硝西泮的结合增加。
Neurochem Res. 2002 Sep;27(9):939-46. doi: 10.1023/a:1020399716812.
5
Changes in [3H]-UK 14304 binding to alpha 2-adrenoceptors in morphine-dependent guinea-pigs.吗啡依赖豚鼠中[3H]-UK 14304与α2-肾上腺素能受体结合的变化
Br J Pharmacol. 1995 Dec;116(8):3125-32. doi: 10.1111/j.1476-5381.1995.tb15114.x.
6
Influence of different benzodiazepines on the experimental morphine abstinence syndrome.不同苯二氮䓬类药物对实验性吗啡戒断综合征的影响。
Psychopharmacology (Berl). 1991;105(2):197-203. doi: 10.1007/BF02244309.
7
Effect of acute and subchronic nicotine treatment on cortical efflux of [3H]-D-aspartate and endogenous GABA in freely moving guinea-pigs.急性和亚慢性尼古丁处理对自由活动豚鼠皮质[3H]-D-天冬氨酸和内源性GABA外流的影响。
Br J Pharmacol. 1991 Sep;104(1):15-20. doi: 10.1111/j.1476-5381.1991.tb12377.x.
8
Inhibitory effects of the psychoactive drug modafinil on gamma-aminobutyric acid outflow from the cerebral cortex of the awake freely moving guinea-pig. Possible involvement of 5-hydroxytryptamine mechanisms.精神活性药物莫达非尼对清醒自由活动豚鼠大脑皮质γ-氨基丁酸流出的抑制作用。5-羟色胺机制可能的参与情况。
Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):461-5. doi: 10.1007/BF00176625.
本文引用的文献
1
Acetylcholine input from the cerebral cortex, choline uptake and muscarinic receptors in morphine-dependent, freely-moving rats.吗啡依赖自由活动大鼠中来自大脑皮层的乙酰胆碱输入、胆碱摄取及毒蕈碱受体
Neuropharmacology. 1980 Jul;19(7):597-605. doi: 10.1016/0028-3908(80)90032-5.
2
Release of GABA from the guinea-pig neocortex induced by electrical stimulation of the 'locus coeruleus' or by norepinephrine.通过电刺激“蓝斑”或去甲肾上腺素诱导豚鼠新皮质释放γ-氨基丁酸。
Brain Res. 1982 Jan 28;232(1):216-21. doi: 10.1016/0006-8993(82)90629-1.
3
Brain acetylcholine during morphine withdrawal.
Neurochem Res. 1984 Mar;9(3):351-66. doi: 10.1007/BF00963983.
4
Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine.去甲肾上腺素能背束损伤不会改变阿片类药物戒断反应，也不会改变可乐定对阿片类药物戒断反应的抑制作用。
Life Sci. 1984 Jan 9;34(2):133-9. doi: 10.1016/0024-3205(84)90583-6.
5
Effects of physostigmine, paraoxon and soman on brain GABA level and metabolism.毒扁豆碱、对氧磷和梭曼对脑γ-氨基丁酸水平及代谢的影响。
Acta Pharmacol Toxicol (Copenh). 1984 Aug;55(2):153-7. doi: 10.1111/j.1600-0773.1984.tb01978.x.
6
Multiple mechanisms of withdrawal from opioid drugs.阿片类药物戒断的多种机制。
Annu Rev Neurosci. 1984;7:443-78. doi: 10.1146/annurev.ne.07.030184.002303.
7
Modulation of cortical acetylcholine and gamma-aminobutyric acid release in freely moving guinea pigs: effects of clonidine and other adrenergic drugs.
J Pharmacol Exp Ther. 1983 Nov;227(2):435-40.
8
GABA induced changes in acetylcholine release from slices of guinea-pig brain.γ-氨基丁酸诱导豚鼠脑切片中乙酰胆碱释放的变化。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Mar;318(4):253-8. doi: 10.1007/BF00501162.
9
Formulation of a morphine implantation pellet suitable for tolerance-physical dependence studies in mice.一种适用于小鼠耐受性-身体依赖性研究的吗啡植入微丸的制剂。
J Pharm Sci. 1970 Mar;59(3):426-7. doi: 10.1002/jps.2600590338.
10
Modification of brain acetylcholine release by morphine and its antagonists in normal and morphine-dependent rats.吗啡及其拮抗剂对正常和吗啡依赖大鼠脑乙酰胆碱释放的影响
Br J Pharmacol. 1974 Jan;50(1):57-62. doi: 10.1111/j.1476-5381.1974.tb09592.x.
Zotero 插件