Vogt A, Vetterlein F, dal Ri H, Schmidt G
Arch Int Pharmacodyn Ther. 1979 May;239(1):86-98.
Afferent impulse activity was recorded in single fibres of the inferior cardiac sympathetic nerve of the cat. When the descending branch of the left coronary artery was ligated for 60 sec an enhancement of afferent impulses was recorded. Elevations in discharge frequency were also induced by injecting bradykinin, epinephrine, and isoprenaline or by general hypoxia due to interruption of the artificial ventilation. When these procedures were after pretreatment with the analgesic agents, acetylsalicylic acid or dipyron a reduction in spike discharge was observed only with bradykinin after application of acetylsalicylic acid. No influence of these pretreatments on the effects of coronary occlusion, general hypoxia and injection of epinephrine and isoprenaline could be observed. These results suggest that bradykinin does not predominate as mediator substance in eliciting ischemic heart pain.
在猫的心下交感神经单纤维中记录传入冲动活动。当结扎左冠状动脉降支60秒时，记录到传入冲动增强。注射缓激肽、肾上腺素和异丙肾上腺素，或因人工通气中断导致的全身性缺氧也会引起放电频率升高。当在这些操作之前用镇痛药乙酰水杨酸或安乃近预处理时，仅在应用乙酰水杨酸后，缓激肽刺激才观察到放电尖峰减少。未观察到这些预处理对冠状动脉闭塞、全身性缺氧以及注射肾上腺素和异丙肾上腺素的影响。这些结果表明，缓激肽并非引发缺血性心痛的主要介质。
