Scherschlicht R, Bonetti E P, Toh C C
Arch Int Pharmacodyn Ther. 1979 Jun;239(2):221-9.
"Nerveside", a phosphopeptide extracted from ox and dog brains by Toh, was injected into one lateral ventricle of four rats previously prepared for the injection as well as for recordings of the EEG of the dorsal hippocampus (field CA1) and sensorimotor cortex. "Nerveside" in doses of 150 and 300 micrograms/animal induced a transient stereotyped behaviour and longer lasting alterations of the EEG activity and vigilance pattern. Wakefulness was increased, slow wave sleep and REM-sleep were diminished. The vigilance pattern was characterized by rapid shifts between all three vigilance states. The effects of "nerveside" were visible for about three hours.
“神经素”是托从牛和狗的大脑中提取的一种磷酸肽，被注射到四只预先准备好用于注射以及记录背侧海马体（CA1区）和感觉运动皮层脑电图的大鼠的一侧脑室中。每只动物注射150微克和300微克剂量的“神经素”会引发短暂的刻板行为以及脑电图活动和警觉模式的更持久变化。觉醒增加，慢波睡眠和快速眼动睡眠减少。警觉模式的特征是在所有三种警觉状态之间快速转换。“神经素”的作用在大约三个小时内可见。
