与安搏律定治疗相关的粒细胞缺乏症。

Agranulocytosis associated with aprindine therapy.

作者信息

Bodenheimer H C, Samarel A M

出版信息

Arch Intern Med. 1979 Oct;139(10):1181-2.

Abstract

Aprindine hydrochloride is an antiarrhythmic drug now under investigation. The drug is most effective in prophylaxis of ventricular dysrhythmias. Previously recognized toxic effects include neurological side effects, nausea, vomiting, as well as a reported association with agranulocytosis. To our knowledge, this is the first report of agranulocytosis associated with documented elevated serum concentrations of aprindine. Further correlation of drug levels with toxic reactions may help in establishing the mechanism of bone marrow suppression.

摘要

盐酸阿普林定是一种正在研究中的抗心律失常药物。该药物在预防室性心律失常方面最为有效。先前已认识到的毒性作用包括神经方面的副作用、恶心、呕吐，以及有报道称与粒细胞缺乏症有关。据我们所知，这是第一例有记录的血清阿普林定浓度升高与粒细胞缺乏症相关的报告。进一步将药物水平与毒性反应进行关联，可能有助于确定骨髓抑制的机制。