Olive D, Buriot D, Brocard O, Griscelli C
Arch Fr Pediatr. 1979 Mar;36(3):298-302.
Two children with chronic granulomatous disease who developed diffuse pulmonary aspergillosis are described. The outcome was satisfactory in one case with miliary disease because the diagnosis was made early by an open lung biopsy. In the other case the diagnosis was delayed and the child died after 7 months with disseminated haematogenous spread of the fungal infection. Although most of the infections of chronic granulomatous disease are bacterial, the abnormalities of phagocyte killing will also predispose to fungal infections. The prolonged survival of affected children because of antibiotic therapy will increase the risk of parasitic and fungal infections.
本文描述了两名患有慢性肉芽肿病并发展为弥漫性肺曲霉菌病的儿童。其中一名患有粟粒性疾病的患儿预后良好，因为通过开胸肺活检早期做出了诊断。另一名患儿诊断延迟，在7个月后因真菌感染经血行播散而死亡。虽然慢性肉芽肿病的大多数感染是细菌性的，但吞噬细胞杀伤功能异常也易导致真菌感染。由于抗生素治疗，患病儿童的长期存活将增加寄生虫和真菌感染的风险。
