Franco D, Gigou M, Szekely A M, Bismuth H
Arch Surg. 1979 Sep;114(9):1064-7. doi: 10.1001/archsurg.1979.01370330086016.
Biliary obstruction of 14 and 28 days induced in the rat an increase of portal pressure (PP) and wedge hepatic vein pressure (WHVP); the higher these were, the longer was the obstruction. Occurrence of portal hypertension seemed related to portal and periportal fibrosis. Relief of obstruction after 14 days by bilioduodenal anastomosis brought back to normal PP and WHVP. In rats with longer obstruction periods, bilioduodenal anastomosis failed to lower PP and WHPV although biological signs of cholestasis returned to normal levels. These results suggest that portal hypertension may arise very shortly after biliary obstruction in rats and that it may persist in animals with a prolonged biliary obstruction despite an efficient bile drainage. In clinical conditions, such results would favor early treatment of lesions that usually cause prolonged bile duct obstruction, such as postoperative bile duct stenosis.
在大鼠中造成14天和28天的胆道梗阻可导致门静脉压力（PP）和肝静脉楔压（WHVP）升高；梗阻时间越长，这些压力升高越明显。门静脉高压的发生似乎与门静脉和门静脉周围纤维化有关。14天后通过胆十二指肠吻合术解除梗阻可使PP和WHVP恢复正常。在梗阻时间较长的大鼠中，尽管胆汁淤积的生物学指标恢复到正常水平，但胆十二指肠吻合术未能降低PP和WHPV。这些结果表明，大鼠在胆道梗阻后很快可能出现门静脉高压，并且尽管胆汁引流有效，但在胆道长期梗阻的动物中门静脉高压可能持续存在。在临床情况下，这些结果将支持对通常导致胆管长期梗阻的病变（如术后胆管狭窄）进行早期治疗。
