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伴眼肌麻痹的肌萎缩侧索硬化症。一项临床病理研究。

Amyotrophic lateral sclerosis with ophthalmoplegia. A clinicopathologic study.

作者信息

Harvey D G, Torack R M, Rosenbaum H E

出版信息

Arch Neurol. 1979 Oct;36(10):615-7. doi: 10.1001/archneur.1979.00500460049005.

DOI:10.1001/archneur.1979.00500460049005
PMID:485889
Abstract

Ophthalmoplegia is rarely observed in patients with amyotrophic lateral sclerosis (ALS). We describe a patient with ALS in whom ophthalmoplegia, initially appearing midway in her course, progressed to total paralysis of extraocular movements by the time of death. In addition to the usual postmortem findings of ALS in the brain stem and spinal cord, there was extensive neuronal loss and gliosis involving the caudal portions of the dorsal and intermediate components of the oculomotor nuclei, the caudal part of the trochlear nuclei, and the abducens nuclei. This represents the first detailed report of the findings in the nuclei of cranial nerves III, IV, and VI in a patient with ALS and ophthalmoplegia.

摘要

眼肌麻痹在肌萎缩侧索硬化症(ALS)患者中很少见。我们描述了一名患有ALS的患者,其眼肌麻痹最初出现在病程中期,到死亡时发展为眼球运动完全麻痹。除了脑干和脊髓中常见的ALS尸检结果外,动眼神经核背侧和中间部分的尾部、滑车神经核尾部以及展神经核存在广泛的神经元丢失和胶质细胞增生。这是首例关于患有ALS和眼肌麻痹患者的动眼神经、滑车神经和展神经核 findings 的详细报告。 (注:这里“findings”直译为“发现”,结合语境可能是指相关神经核的病变等具体情况,但因未明确具体所指,译文保留英文更合适)

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