Petterson D S, Howlett R M, Robertson T A, Papadimitriou J M
Aust J Exp Biol Med Sci. 1979 Apr;57(2):211-23. doi: 10.1038/icb.1979.22.
A number of experiments are described in which the effect of the toxins causing lupinosis on cell morphology and motility is examined. The toxins arrested cells in metaphase leading to abnormal profiles, and inhibited leucocyte migration. Similar results were obtained with colchicine on cell division and, from the evidence obtained, it is suggested that the mechanism of action of the two agents is similar and that the same binding sites are probably involved.
本文描述了多项实验，研究了导致羽扇豆中毒的毒素对细胞形态和运动性的影响。这些毒素使细胞停滞在中期，导致异常形态，并抑制白细胞迁移。秋水仙碱对细胞分裂也得到了类似结果，根据所获证据表明，这两种药物的作用机制相似，可能涉及相同的结合位点。
