Casdorph H R
Calif Med. 1967 Apr;106(4):293-5.
The results of administration of cholestyramine to 19 patients for periods of two to 21 months are reported. All patients consistently taking the drug obtained a significant reduction in the serum cholesterol. The average reduction was 26 per cent and the range was from 16 to 52 per cent. Cholestyramine acts as a bile acid sequestering resin, causing an increased loss of bile salts (cholates) in the stool. The drug acts by increasing the normal excretory pathway for cholesterol.
报告了对19名患者使用消胆胺治疗两至21个月的结果。所有持续服用该药物的患者血清胆固醇均显著降低。平均降低26%，范围为16%至52%。消胆胺作为一种胆汁酸螯合树脂，导致粪便中胆盐（胆酸）损失增加。该药物通过增加胆固醇的正常排泄途径起作用。
