手术创伤对大鼠肌肉蛋白质周转的影响。一个严重的方法学误解。
The effect of surgical trauma on muscle protein turnover in rats. A serious methodological misunderstanding.
作者信息
Millward D J
出版信息
Biochem J. 1979 May 15;180(2):427-9. doi: 10.1042/bj1800427.
Abstract
The reported rates of protein degradation in a recent paper on the effect of surgical trauma on muscle protein turnover [Hoover-Plow & Clifford (1978) Biochem. J. 176, 137--142] have no real meaning because of a serious methodological misunderstanding by the authors. In addition, there are problems involved in the determination of synthesis rates, so that the reported effects of trauma on muscle protein turnover can be discounted.
摘要
在最近一篇关于手术创伤对肌肉蛋白质周转影响的论文中所报道的蛋白质降解率[胡佛 - 普洛与克利福德（1978年），《生物化学杂志》176卷，第137 - 142页]没有实际意义，因为作者存在严重的方法学误解。此外，在合成率的测定方面也存在问题，因此所报道的创伤对肌肉蛋白质周转的影响不可信。
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本文引用的文献
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Protein turnover in skeletal muscle. II. The effect of starvation and a protein-free diet on the synthesis and catabolism of skeletal muscle proteins in comparison to liver.骨骼肌中的蛋白质周转。II. 与肝脏相比，饥饿和无蛋白饮食对骨骼肌蛋白质合成和分解代谢的影响。
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The effect of surgical trauma on muscle protein turnover in rats.手术创伤对大鼠肌肉蛋白质周转的影响。
Biochem J. 1978 Oct 15;176(1):137-42. doi: 10.1042/bj1760137.
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