赭曲霉毒素对大鼠肾糖异生的抑制作用。
Inhibition of renal gluconeogenesis in rats by ochratoxin.
作者信息
Meisner H, Selanik P
出版信息
Biochem J. 1979 Jun 15;180(3):681-4. doi: 10.1042/bj1800681.
In kidney-cortex slices from rats fed on 2.0 mg of ochratoxin A/kg per day for 2 days, gluconeogenesis from pyruvate is decreased by 26%, and renal phosphoenolpyruvate carboxykinase activity is lowered by about 55%. Gluconeogenesis from 10 mM-lactate or 20 mM-malate or -glutamine is also significantly decreased. Hepatic phosphoenolpyruvate carboxykinase is unchanged or increased, and hexokinase activity in kidney and liver remains unaffected. We conclude that ochratoxin A in vivo is an inhibitor of renal phosphoenolpyruvate carboxykinase activity, which is responsible, at least in part, for the block in renal gluconeogenesis.
在每天以2.0毫克赭曲霉毒素A/千克的剂量喂食大鼠2天的肾皮质切片中，丙酮酸的糖异生作用降低了26%，肾磷酸烯醇丙酮酸羧激酶活性降低了约55%。10毫摩尔乳酸、20毫摩尔苹果酸或谷氨酰胺的糖异生作用也显著降低。肝磷酸烯醇丙酮酸羧激酶未发生变化或有所增加，肾和肝中的己糖激酶活性未受影响。我们得出结论，体内赭曲霉毒素A是肾磷酸烯醇丙酮酸羧激酶活性的抑制剂，这至少在一定程度上导致了肾糖异生的阻滞。
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