Gunther M
Lancet. 1975 Feb 22;1(7904):441-2. doi: 10.1016/s0140-6736(75)91504-4.
In many mammals infant behaviour imposes a period during which the young will only take the mother's milk. It is suggested that the immunological components of the milk serve in this period to augment the baby's immune system while he traverses from the antigenic isolation of a fetus to his independent defence. In humans almost all cot deaths occur during this phase. Diverse statistics relating to factors associated with greater risk of cot death are drawn on, suggesting that a number of seemingly unconnected factors can all (including lack of breast-feeding) be interpreted as potential immunity defaults. This interpretation lends support to the idea of an immune mechanism underlying cot death which in some way is an abnormal response resulting from the default and which, with at least one other precipitating mechanism, leads to death.
在许多哺乳动物中,幼崽的行为会导致一段时期,在此期间幼崽只吃母乳。有人认为,在此期间,母乳中的免疫成分有助于增强婴儿的免疫系统,因为婴儿正从胎儿期的抗原隔离状态过渡到独立防御状态。在人类中,几乎所有的婴儿猝死都发生在这个阶段。文中引用了与婴儿猝死风险增加相关因素的各种统计数据,表明许多看似不相关的因素(包括缺乏母乳喂养)都可以被解释为潜在的免疫缺陷。这种解释支持了婴儿猝死存在免疫机制的观点,即婴儿猝死在某种程度上是由免疫缺陷导致的异常反应,并且至少与另一种促发机制共同导致死亡。