Carnie S, Israelachvili J N, Pailthorpe B A
Biochim Biophys Acta. 1979 Jul 5;554(2):340-57. doi: 10.1016/0005-2736(79)90375-4.
Predictions, based on a previously developed theory, of the radii and asymmetric lipid distribution of mixed phosphatidylcholine/lysophosphatidylcholine and phosphatidylcholine/cholesterol vesicles of variable composition are presented. The results compare well with available experimental data, except for cis-unsaturated phosphatidylcholine/cholesterol vesicles at high concentrations of cholesterol. It is concluded that specific lipid-lipid interactions need not be invoked for saturated and trans-unsaturated phosphatidylcholine mixed with lysophosphatidylcholine or cholesterol. A discussion of the effect of packing stresses on induced flip-flop and non-spherical vesicles is also presented.
本文基于先前发展的理论，给出了不同组成的混合磷脂酰胆碱/溶血磷脂酰胆碱以及磷脂酰胆碱/胆固醇囊泡的半径和不对称脂质分布的预测结果。除了高胆固醇浓度下的顺式不饱和磷脂酰胆碱/胆固醇囊泡外，该结果与现有实验数据吻合良好。研究得出结论，对于与溶血磷脂酰胆碱或胆固醇混合的饱和及反式不饱和磷脂酰胆碱，无需考虑特定的脂质-脂质相互作用。文中还讨论了堆积应力对诱导翻转和非球形囊泡的影响。
