McMullen N T, Almli C R
Brain Res Bull. 1979 May-Jun;4(3):373-80. doi: 10.1016/s0361-9230(79)80015-5.
Male and female albino rat pups sustained septal destruction at 10 days of age and body weight and water intakes were measured daily throughout development until 200 days of age. During development the septal and control rats received a battery of drinking tests (e.g., cellular dehydration, hypovolemia, renin). Septal rats (males and females) were hyperdipsic for daily water intakes as early as 31 days of age and the daily hyperdipsia persisted through 200 days of age. On the battery of drinking tests, septal rats consumed water at control volumes on all tests except water deprivation (following which females were hyperdipsic) and food deprivation (during which both males and females were hyperdipsic). Urine output-water intake relationships were determined, and a series of food deprivation tests were conducted during development to determine the etiology of the developmental septal hyperdipsia. All results suggest that hyperdipsia associated with septal destruction during the preweaning period is a primary condition and not secondary to altered output mechanisms, abnormal feeding-drinking patterns, or displacement behavior.
雄性和雌性白化病幼鼠在10日龄时接受了中隔破坏手术，并在整个发育过程中每天测量体重和饮水量，直至200日龄。在发育过程中，中隔破坏组和对照组大鼠接受了一系列饮水测试（如细胞脱水、血容量不足、肾素）。中隔破坏组大鼠（雄性和雌性）早在31日龄时每日饮水量就出现增多，且每日饮水量增多持续至200日龄。在一系列饮水测试中，除了禁水（禁水后雌性大鼠饮水量增多）和禁食（禁食期间雄性和雌性大鼠饮水量均增多）外，中隔破坏组大鼠在所有测试中的饮水量均与对照组相同。测定了尿量与饮水量的关系，并在发育过程中进行了一系列禁食测试，以确定发育性中隔破坏所致饮水量增多的病因。所有结果表明，断奶前中隔破坏相关的饮水量增多是一种原发性情况，并非继发于输出机制改变、异常的摄食-饮水模式或替代行为。
