The effect of spironolactone on the arterial water, cation, and norepinephrine contents of control and 'one-kidney-one-clip' hypertensive dogs.

Spironolactone at 10 mg per kilogram per day was given to control and 'one-kidney-one-clip' hypertensive dogs for 6--7 weeks. Compared with untreated animals the treated animals had a lower arterial water content, a higher arterial, myocardial, and skeletal muscle sodium content, and variable changes in tissue potassium concentrations.