螺内酯对正常对照和“单肾单夹”高血压犬动脉内水分、阳离子及去甲肾上腺素含量的影响。
The effect of spironolactone on the arterial water, cation, and norepinephrine contents of control and 'one-kidney-one-clip' hypertensive dogs.
作者信息
Constantopoulos G, Gutkowska J, Genest J
出版信息
Can J Physiol Pharmacol. 1979 Jun;57(6):631-6. doi: 10.1139/y79-096.
DOI:10.1139/y79-096
PMID:487270
Abstract
Spironolactone at 10 mg per kilogram per day was given to control and 'one-kidney-one-clip' hypertensive dogs for 6--7 weeks. Compared with untreated animals the treated animals had a lower arterial water content, a higher arterial, myocardial, and skeletal muscle sodium content, and variable changes in tissue potassium concentrations.
摘要
每天每千克体重给予10毫克螺内酯，对“单肾单夹”高血压犬进行6至7周的治疗。与未治疗的动物相比，治疗后的动物动脉含水量较低，动脉、心肌和骨骼肌钠含量较高，组织钾浓度变化不定。
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