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[法裔加拿大环境下的儿童脑肿瘤]

[Brain tumors in children in a French Canadian environment].

作者信息

Renevey F, Amyot Y, Geoffroy G, Vanasse M

出版信息

Can J Neurol Sci. 1979 Aug;6(3):329-35.

PMID:487325
Abstract

Between 1964 and 1976, we have seen 197 cases of cerebral tumors in children. We have studied the frequency of each histological group of tumors, their localization, the results of the clinical investigation, their clinical manifestations and the prognosis for each group. This study has confirmed that in children brain tumors are more frequently localized in the posterior fossa (56.4%). As in other series, tumors derived from the glia represent nearly 80% of the total. Clinically, increased intro-cranial pressure is the most frequent manifestation of posterior fossa lesion (75% of cases) while cerebellar involvement was seen in 60% of these children. Brain lesions and supratentorial tumors are more insidious in their presentation and their clinical manifestations more diversified. The EEG appeared useful in the investigation of brain tumors and showed irregularities in 78% of our patients. However, a more specific diagnosis requirelography. As in previous series, the mortality rate remained high in the children we have followed, particularly for some groups of tumors (glioblastoma, medulloblastoma, brain stem lesions). It is to be hoped that with the introduction of the CT Scan, the improvement of neurosurgical techniques and the use of immuno and chemotherapy, the prognosis may be improved.

摘要

1964年至1976年间,我们共收治197例儿童脑肿瘤患者。我们研究了各组织学类型肿瘤的发生频率、肿瘤部位、临床检查结果、临床表现以及各类型的预后情况。该研究证实,儿童脑肿瘤多位于后颅窝(56.4%)。与其他系列研究一样,胶质来源的肿瘤占总数的近80%。临床上,颅内压升高是后颅窝病变最常见的表现(75%的病例),其中60%的患儿有小脑受累情况。脑实质病变和幕上肿瘤的表现较为隐匿,临床表现更为多样。脑电图对脑肿瘤检查似乎有用,我们78%的患者脑电图显示异常。然而,更具特异性的诊断需要进行造影检查。与之前的系列研究一样,在我们随访的儿童中死亡率仍然很高,尤其是某些类型的肿瘤(胶质母细胞瘤、髓母细胞瘤、脑干病变)。希望随着CT扫描技术的引入、神经外科技术的改进以及免疫治疗和化疗的应用,预后情况能够得到改善。

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