Grant E C
Br Med J. 1968 Aug 17;3(5615):402-5. doi: 10.1136/bmj.3.5615.402.
The incidence of headaches during the first year on oral cotraceptives corrleates closely with the incidence of well-developed arterioles in endometrial biopsy specimens. This relationship appears to depend on the ratio between progestogenic and oestrogenic components of the pill as well as the particular steroids. Therefore endometrial biopsies are useful for assessing the vascular response to an oral contraceptive and also provide a short cut to clinical evaluation of new formulations.
口服避孕药第一年头痛的发生率与子宫内膜活检标本中发育良好的小动脉的发生率密切相关。这种关系似乎取决于避孕药中孕激素和雌激素成分的比例以及特定的类固醇。因此,子宫内膜活检有助于评估口服避孕药引起的血管反应,也为新配方的临床评估提供了一条捷径。