Whiting P H, Ross I S, Borthwick L J
Clin Chim Acta. 1979 Oct 1;97(2-3):191-5. doi: 10.1016/0009-8981(79)90415-7.
N-Acetyl-beta-D-glucosaminidase (NAG) activity has been measured in the serum and urine of primary and secondary diabetics and in primary diabetics with microangiopathy. NAG activity has also been measured in the tears of diabetics with ocular complications and diabetics with no ocular changes. Results have shown significantly higher levels of urinary NAG in diabetics with proteinuria (p less than 0.001) and proteinuria and retinopathy (p less than 0.001). There was no correlation between urinary NAG activity and serum creatinine (r = 0.28) or urinary NAG and the degree of proteinuria (r = 0.24). Increased urinary NAG levels were also observed in secondary diabetes associated with haemochromatosis and acromegaly. Significantly higher serum NAG levels were found in newly diagnosed diabetics (p less than 0.01) and significantly lower levels in chemical diabetics (p less than 0.01). Compared to non-diabetic controls tear NAG levels were significantly higher in the diabetic controls (p less than 0.01), in diabetics with retinopathy (p less than 0.01), and in diabetics with cataract formation (p less than 0.05). An assessment of this enzyme is made in relation to the development of diabetic microangiopathy.
已对原发性和继发性糖尿病患者以及患有微血管病变的原发性糖尿病患者的血清和尿液中的N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性进行了测定。还对患有眼部并发症的糖尿病患者和无眼部变化的糖尿病患者的泪液中的NAG活性进行了测定。结果显示，蛋白尿糖尿病患者（p<0.001）以及蛋白尿合并视网膜病变的糖尿病患者（p<0.001）的尿NAG水平显著更高。尿NAG活性与血清肌酐（r=0.28）或尿NAG与蛋白尿程度（r=0.24）之间无相关性。在与血色素沉着症和肢端肥大症相关的继发性糖尿病中也观察到尿NAG水平升高。新诊断的糖尿病患者血清NAG水平显著更高（p<0.01），而化学性糖尿病患者血清NAG水平显著更低（p<0.01）。与非糖尿病对照组相比，糖尿病对照组（p<0.01）、患有视网膜病变的糖尿病患者（p<0.01）以及患有白内障的糖尿病患者（p<0.05）的泪液NAG水平显著更高。对该酶进行了与糖尿病微血管病变发展相关的评估。
