腺嘌呤磷酸核糖转移酶（APRT）缺乏症的免疫学研究
Immunological investigation in adenine phosphoribosyl transferase (APRT) deficiency.
作者信息
Stevens W J, Peetermans M E, Van Acker K J
出版信息
Clin Exp Immunol. 1979 Jun;36(3):364-70.
Abstract
In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins and determining lymphocyte membrane immunoglobulins by immunofluorescence. Delayed cutaneous hypersensitivity was also assayed. The absence of gross immunological deficiency in the homozygotes, as well as in the heterozygotes, suggests that the APRT-mediated pathway of purine metabolism is relatively unimportant for lymphocyte function.
摘要
在一个部分或完全缺乏腺嘌呤磷酸核糖转移酶（APRT）的家族中，通过计数玫瑰花结形成细胞、研究淋巴细胞对植物血凝素（PHA）、刀豆蛋白A（Con A）和商陆有丝分裂原（PWM）的转化、检测血清免疫球蛋白以及通过免疫荧光法测定淋巴细胞膜免疫球蛋白，来评估T细胞和B细胞功能。还检测了迟发型皮肤超敏反应。纯合子以及杂合子中均未出现明显的免疫缺陷，这表明APRT介导的嘌呤代谢途径对淋巴细胞功能相对不重要。
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