Rieckmann K H, McNamara J V, Frischer H, Stockert T A, Carson P E, Powell R D
Bull World Health Organ. 1968;38(4):625-32.
Studies with 3 volunteers were conducted to determine the effects of a combination of sulfadiazine and pyrimethamine and the effects of primaquine upon mature gametocytes of a strain of chloroquine-resistant Plasmodium falciparum-the Malayan (Camp.) strain. One volunteer was treated with sulfadiazine and pyrimethamine; two other volunteers each received a single dose of 45 mg of primaquine base. The combination of sulfadiazine and pyrimethamine, although active against blood schizonts, did not exert a marked sporontocidal effect against the Malayan (Camp.) strain. In sharp contrast, primaquine, although not effective as a blood schizontocide, exerted a marked gametocytocidal and sporontocidal effect against this strain.The findings emphasize the need for further studies of the sporontocidal and gametocytocidal effects of drugs, particularly primaquine, against chloroquine-resistant strains of P. falciparum and suggest that primaquine may come to play an important role in preventing the transmission of such strains.
对3名志愿者进行了研究，以确定磺胺嘧啶和乙胺嘧啶联合用药的效果，以及伯氨喹对一株耐氯喹恶性疟原虫——马来亚（坎普）株成熟配子体的影响。一名志愿者接受了磺胺嘧啶和乙胺嘧啶治疗；另外两名志愿者每人接受了45毫克伯氨喹碱基的单剂量治疗。磺胺嘧啶和乙胺嘧啶联合用药虽然对血液裂殖体有活性，但对马来亚（坎普）株没有明显的杀孢子体作用。与之形成鲜明对比的是，伯氨喹虽然作为血液裂殖体杀灭剂无效，但对该株有明显的杀配子体和杀孢子体作用。这些发现强调了进一步研究药物，特别是伯氨喹，对耐氯喹恶性疟原虫株的杀孢子体和杀配子体作用的必要性，并表明伯氨喹可能在预防此类菌株的传播中发挥重要作用。
