Brater C, Anderson S, Muckleroy C
Clin Pharmacol Ther. 1979 Oct;26(4):437-41. doi: 10.1002/cpt1979264437.
Azosemide is a new loop diuretic which has been shown to affect solute transport proximal to the diluting segment. We assessed the effects of chronic administration of azosemide in normal subjects on low and normal salt diets. In both, there was compensatory renin release and aldosterone secretion, but the subjects on the low sodium diet developed striking hyperuricemia and metabolic alkalosis and were symptomatic, whereas those on the normal diet compensated to the extent that there were only minor changes.
阿佐塞米是一种新型袢利尿剂，已被证明会影响稀释段近端的溶质转运。我们评估了正常受试者长期服用阿佐塞米对低盐饮食和正常盐饮食的影响。在这两种饮食情况下，都有肾素释放和醛固酮分泌的代偿，但低钠饮食的受试者出现了明显的高尿酸血症和代谢性碱中毒且有症状，而正常饮食的受试者代偿程度较好，仅有轻微变化。
