豚鼠淋巴结和脾脏中不同特异性抗体形成细胞的分布。
Distribution of antibody-forming cells of different specificities in the lymph nodes and spleens of guinea pigs.
作者信息
Green I
出版信息
J Exp Med. 1968 Oct 1;128(4):729-51. doi: 10.1084/jem.128.4.729.
The distribution of antibody-forming cells of different specificities in the lymph nodes and spleens of guinea pigs immunized with two separate antigens or with antigens bearing two determinants was studied. When animals were immunized with two soluble protein antigens or antigens in which the two antigenic determinants were on the same molecule, antibody-forming cells of different specificities were always randomly intermixed. However, when animals were immunized with two heat-aggregated particulate protein antigens and then boosted with soluble protein antigens, cells of different specificities were often seen to occur in groups. These results suggest that antibody-forming cells may not arise by the antigen-stimulated proliferation of precommitted antibody-forming cells, but rather antibody-forming cells arise by a transformation of uncommitted precursor cells as the result of their interactions with a locally produced material derived from the processing of antigen.
研究了用两种不同抗原或带有两种决定簇的抗原免疫豚鼠后，其淋巴结和脾脏中不同特异性抗体形成细胞的分布情况。当用两种可溶性蛋白质抗原或两种抗原决定簇位于同一分子上的抗原免疫动物时，不同特异性的抗体形成细胞总是随机混合在一起。然而，当用两种热聚集的颗粒性蛋白质抗原免疫动物，然后再用可溶性蛋白质抗原进行加强免疫时，常常可以看到不同特异性的细胞成组出现。这些结果表明，抗体形成细胞可能不是由预先确定的抗体形成细胞经抗原刺激增殖产生的，而是未确定的前体细胞在与抗原加工产生的局部产生的物质相互作用的结果下通过转化产生抗体形成细胞。
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