参与免疫反应的细胞。十一、在免疫耐受兔中确定抗原反应性细胞为耐受细胞。
Cells involved in the immune response. XI. Identification of the antigen-reactive cell as the tolerant cell in the immunologically tolerant rabbit.
作者信息
Abdou N I, Richter M
出版信息
J Exp Med. 1969 Jul 1;130(1):165-84. doi: 10.1084/jem.130.1.165.
Rabbits were made immunologically tolerant to either human serum albumin or bovine gamma globulin by the neonatal administration of antigen. At 10 wk of age, they were challenged with the tolerogenic antigen and found to be non-responsive. However, these tolerant rabbits could respond with humoral antibody formation directed toward the tolerogenic antigen if they were treated with normal, allogeneic bone marrow or bone marrow obtained from a rabbit made tolerant toward a different antigen. They were incapable of responding if they were given bone marrow obtained from a rabbit previously made tolerant to the tolerogenic antigen. Irradiated rabbits were unable to respond if treated with tolerant bone marrow, but could respond well if given normal bone marrow. Since it has previously been demonstrated that the antibody-forming cell, in an irradiated recipient of allogeneic bone marrow, is of recipient and not donor origin, the data presented strongly indicate that the unresponsive cell in the immunologically tolerant rabbit is the antigen-reactive cell.
通过在新生期给予抗原，使兔子对人血清白蛋白或牛γ球蛋白产生免疫耐受。在10周龄时，用致耐受性抗原对它们进行攻击，发现它们无反应。然而，如果用正常的同种异体骨髓或从对不同抗原产生耐受的兔子获得的骨髓对这些耐受兔子进行处理，它们能够针对致耐受性抗原产生体液抗体形成反应。如果给它们注射先前对致耐受性抗原产生耐受的兔子的骨髓，它们则无反应能力。经照射的兔子如果用耐受骨髓处理则无反应能力，但如果给予正常骨髓则反应良好。由于先前已证明，在同种异体骨髓的照射受体中，抗体形成细胞是受体来源而非供体来源，所呈现的数据有力地表明，免疫耐受兔子中的无反应细胞是抗原反应性细胞。
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