尼古丁对海拉细胞细胞分裂的影响。
The effects of nicotine on cell division of HeLa cells.
作者信息
Ved Brat S S, Sisken J E, Anderson R L
出版信息
Eur J Cell Biol. 1979 Aug;19(3):250-4.
PMID:488124
Abstract
A time lapse cinemicrographic study shows that, at low concentrations, nicotine can speed up cytokinesis and, at high concentrations, prolong the duration of metaphase in HeLa cells. Based upon the known effects of the alkaloid in other systems, it appears that it may stimulate microfilament activity and inhibit microtubule function by increasing the level of cytosolic calcium ions.
摘要
一项延时电影显微摄影研究表明，在低浓度下，尼古丁可加速海拉细胞的胞质分裂，而在高浓度下，则会延长其分裂中期的持续时间。基于该生物碱在其他系统中的已知作用，似乎它可能通过提高胞质钙离子水平来刺激微丝活性并抑制微管功能。
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