Myslivecek J, Stípek S
Exp Brain Res. 1979 Jul 2;36(2):343-57. doi: 10.1007/BF00238916.
A complex stimulation regimen (visual, auditory, and somesthetic-kinesthetic with forced movements, 30 times for 30 min each within 14 days) increased significantly the amplitudes of visual cortical evoked potentials (EPs) in adult rats if applied during the second postnatal fortnight. The EP increase after stimulation during the first 14 days after birth was not significant. Visual stimulation alone was compared with complex stimulation (visual plus forced movements) during the 2nd postnatal fortnight. More specific local changes in the visual cortex were revealed in brain biochemistry (lower DNA concentration, more RNA and protein per cell) and cortical electrogenesis (enhanced visual EPs) after visual stimulation alone, whereas complex stimulation induced more diffuse changes and rather profoundly influenced higher nervous functions (viz., memory retrieval - improved 24-h). Involvement of both specific and nonspecific mechanisms in the aftereffects of early stimulation is indicated.
一种复杂的刺激方案（视觉、听觉以及伴有强制运动的躯体感觉 - 动觉刺激，在14天内每天30次，每次30分钟），如果在出生后第二周对成年大鼠施加，可显著增加视觉皮层诱发电位（EPs）的幅度。在出生后的头14天内施加刺激后，EPs的增加并不显著。将出生后第二周单独的视觉刺激与复杂刺激（视觉加强制运动）进行了比较。单独视觉刺激后，在脑生物化学（较低的DNA浓度，每个细胞更多的RNA和蛋白质）和皮层电发生（增强的视觉EPs）方面揭示了视觉皮层中更具体的局部变化，而复杂刺激则引起更广泛的变化，并对高级神经功能（即记忆恢复 - 24小时内改善）产生更深刻的影响。这表明早期刺激的后效应涉及特异性和非特异性机制。
