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Protein synthesis inhibition induced by dimethylnitrosamine and diethylnitrosamine on isolated rat hepatocytes.

作者信息

Mattei E, Delpino A, Ferrini U

出版信息

Experientia. 1979 Sep 15;35(9):1213-5. doi: 10.1007/BF01963297.

DOI:10.1007/BF01963297
PMID:488284
Abstract

Time- and dose-dependent protein synthesis inhibition takes place following exposure to high doses of dimethylnitrosamine (DMN) or diethylnitrosamine (DENA) in isolated rat hepatocytes. The ability of DENA to depress protein synthesis is 5-fold higher than that of DMN. Cells inhibited by 60 min exposure to DMN or DENA, and then incubated in a nitrosamine-free medium, regain their initial rate of protein synthesis. This recovery is faster and more complete for DENA-treated cells.

摘要

相似文献

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Protein synthesis inhibition induced by dimethylnitrosamine and diethylnitrosamine on isolated rat hepatocytes.
Experientia. 1979 Sep 15;35(9):1213-5. doi: 10.1007/BF01963297.
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引用本文的文献

1
Analysis of translation products synthesized in isolated rat hepatocytes treated with diethylnitrosamine.
Experientia. 1984 Dec 15;40(12):1377-9. doi: 10.1007/BF01951898.

本文引用的文献

1
Toxic liver injury. Inhibition by dimethylnitrosamine of incorporation of labelled amino acids into proteins of rat-liver preparations in vitro.中毒性肝损伤。二甲基亚硝胺对体外标记氨基酸掺入大鼠肝脏制剂蛋白质的抑制作用。
Biochem J. 1960 Jul;76(1):109-16. doi: 10.1042/bj0760109.
2
Studies on the denaturation of biological macromolecules by chemical carcinogens. 3. Optical rotatory dispersion and light-scattering changes of ovalbumin during denaturation and aggregation by water-soluble carcinogens.化学致癌物对生物大分子的变性作用研究。3. 水溶性致癌物使卵清蛋白变性和聚集过程中的旋光色散及光散射变化
Biochim Biophys Acta. 1966 Oct 10;126(2):274-85. doi: 10.1016/0926-6585(66)90064-1.
3
Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.
大鼠肝细胞的制备。3. 组织分散的酶学要求。
Exp Cell Res. 1973 Dec;82(2):391-8. doi: 10.1016/0014-4827(73)90357-1.
4
Preparation of rat liver cells. I. Effect of Ca 2+ on enzymatic dispersion of isolated, perfused liver.大鼠肝细胞的制备。I. Ca²⁺ 对离体灌注肝脏酶分散作用的影响。
Exp Cell Res. 1972 Oct;74(2):450-4. doi: 10.1016/0014-4827(72)90400-4.
5
Protein chain initiation in vitro by liver cell components from DMNA-treated rats.用二甲基亚硝胺处理过的大鼠的肝细胞成分进行体外蛋白质链起始反应。
Chem Biol Interact. 1975 Dec;11(6):589-98. doi: 10.1016/0009-2797(75)90033-2.
6
Incorporation of radioactive amino acids into protein in isolated rat hepatocytes.
Biochim Biophys Acta. 1976 Sep 6;442(3):391-404. doi: 10.1016/0005-2787(76)90313-0.
7
Ammonia inhibition of protein degradation in isolated rat hepatocytes. Quantitative ultrastructural alterations in the lysosomal system.氨对离体大鼠肝细胞蛋白质降解的抑制作用。溶酶体系统的定量超微结构改变。
Exp Cell Res. 1976 Jul;100(2):276-80. doi: 10.1016/0014-4827(76)90148-8.
8
Activity of partially purified protein chain initiation factors from the livers of dimethylnitrosamine-treated rats.二甲基亚硝胺处理大鼠肝脏中部分纯化的蛋白质链起始因子的活性
Chem Biol Interact. 1978 Feb;20(2):149-61. doi: 10.1016/0009-2797(78)90049-2.
9
Use of high concentrations of dimethylnitrosamine in bacterial lethality, mutagenesis, and enzymological studies.高浓度二甲基亚硝胺在细菌致死率、诱变及酶学研究中的应用。
Cancer Res. 1978 Jan;38(1):226-8.
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Criteria of viability of isolated liver cells.分离肝细胞的活力标准。
Hoppe Seylers Z Physiol Chem. 1975 Jun;356(6):827-38. doi: 10.1515/bchm2.1975.356.s1.827.