Williams J D, Thomlinson J L, Cole J G, Cope E
Br Med J. 1969 Jan 4;1(5635):29-31. doi: 10.1136/bmj.1.5635.29.
In this study mid-stream specimens of urine were collected from all new patients attending a gynaecological outpatient department and tested for significant bacteriuria. Those having an asymptomatic infection were folloWed up, treated, and investigated adiologically.Of 1,506 women screened for bacteriuria 82 (5.4%) were found to have a persistent infection. The predominant organism was Escherichia coli, present in 83% of infections. Treatment with sulphonamides produced a good cure rate, which was improved by ampicillin given to failures. Some patients, however, had infections that persisted or recurred despite several antibiotics. The radiological investigations showed that a high proportion of women with asymptomatic urinary infection had severe renal disease which was quite symptomless. This was more pronounced in those with persistent or recurrent infections.
在本研究中,从妇科门诊的所有新患者中收集了中段尿标本,并检测是否存在显著菌尿。对那些无症状感染的患者进行随访、治疗并进行放射学检查。在筛查菌尿的1506名女性中,发现82名(5.4%)患有持续性感染。主要病原体是大肠杆菌,在83%的感染中存在。磺胺类药物治疗有良好的治愈率,治疗失败的患者加用氨苄西林后治愈率提高。然而,一些患者尽管使用了几种抗生素,感染仍持续或复发。放射学检查表明,无症状尿路感染的女性中,有很大一部分患有严重的肾脏疾病,但毫无症状。这在那些持续性或复发性感染的患者中更为明显。