Harris W A, Harden T E, Dawson E B
Fertil Steril. 1979 Oct;32(4):455-9. doi: 10.1016/s0015-0282(16)44304-9.
The apparent effect of ascorbic acid therapy for nonspecific spermagglutination on semen levels of ascorbic acid as well as macro- and micrometals was determined in 20 men (ages 25 to 38). Pretreatment diagnosis was based on infertility and relatively low ratings in sperm density, motility, motility index, and semen volume, and were associated with large numbers of abnormal sperm, sperm precursors, and leukocytes. The pretreatment levels of ascorbic acid, sodium, iron, potassium, zinc, manganese, lead, magnesium, and copper were measured in each patient's semen and compared with levels following 60 days of dietary vitamin C supplementation (1.0 gm/day). Analysis of the vitamin C preparation prescribed revealed that each subject was given an impure ascorbic acid medication to supplement a normal diet. Therefore, the significant increases in levels of ascorbic acid and metals in semen following therapy could not be attributed to ascorbic acid alone, nor, similarly, the improved physical parameters of each subject's semen following therapy; no apparent spermagglutination and restored fertility may be due to the interaction of ascorbic acid with cations found in semen.
在20名年龄在25至38岁的男性中，测定了抗坏血酸疗法对非特异性精子凝集的明显效果，以及精液中抗坏血酸以及常量和微量元素的水平。治疗前的诊断基于不育以及精子密度、活力、活力指数和精液量的相对较低评分，并且与大量异常精子、精子前体和白细胞有关。测量了每位患者精液中抗坏血酸、钠、铁、钾、锌、锰、铅、镁和铜的治疗前水平，并与补充膳食维生素C（1.0克/天）60天后的水平进行比较。对所开的维生素C制剂的分析表明，每位受试者都服用了不纯的抗坏血酸药物来补充正常饮食。因此，治疗后精液中抗坏血酸和金属水平的显著增加不能仅归因于抗坏血酸，同样，治疗后每位受试者精液的物理参数改善也不能仅归因于此；无明显精子凝集和生育力恢复可能是由于抗坏血酸与精液中发现的阳离子相互作用所致。
