威尔逊病中的溶酶体变化和肠细胞铜沉积
Lysosomal changes and enterocytic copper deposits in Wilson's disease.
作者信息
Gasbarrini G, Corazza G R, Bonvicini F
出版信息
Digestion. 1979;19(5):346-8. doi: 10.1159/000198388.
PMID:488556
Abstract
In 4 siblings, of whom 2 had symptoms of Wilson's disease, electron microscopy showed that the number and size of lysosomes in the enterocytes were increased compared with controls. Electron-dense aggregates, observed near the lysosomes in the 2 symptomatic patients and 1 other sibling, were shown, by means of a microanalytical method, to contain copper. These findings could suggest a possible role of the small intestine in Wilson's disease.
摘要
在4名兄弟姐妹中，其中2人有威尔逊氏病的症状，电子显微镜检查显示，与对照组相比，肠细胞中溶酶体的数量和大小增加。通过微量分析方法发现，在2名有症状的患者和另一名兄弟姐妹的溶酶体附近观察到的电子致密聚集体含有铜。这些发现可能提示小肠在威尔逊氏病中可能发挥的作用。
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