Gershon R K, Carter R L, Kondo K
Science. 1968 Feb 9;159(3815):646-8. doi: 10.1126/science.159.3815.646.
Hamsters grafted with an allotransplantable lymphoma that does not metastasize develop a state of concomitant immunity which renders them refractory to reinoculation with cells of the same tumor. Removal of the tumor 7 days after transplantation rapidly leads to a decrease in immunity, the production of enhancing antibodies, and the appearance of metastatic deposits which are probably derived from preexisting tumor cells in the blood and lymphoid tissuces.
移植了不会发生转移的同种可移植淋巴瘤的仓鼠会产生伴随免疫状态，这使得它们对再次接种相同肿瘤的细胞具有抗性。移植后7天切除肿瘤会迅速导致免疫力下降、增强抗体的产生以及转移瘤的出现，这些转移瘤可能源自血液和淋巴组织中预先存在的肿瘤细胞。
