Draper P, Rees R J, Waters M F
Clin Exp Immunol. 1968 Oct;3(8):809-16.
Two methods for preparing a suspension of from tissues of infected mice, using enzyme digestion, are described. The suspensions of mouse lepromin' were compared with standard human lepromin as skin test antigens in forty-nine leprosy patients with various types of the disease. The reactions to mouse lepromin' were closely similar to those produced by standard lepromin, and patients with lepromatous leprosy failed to react to either antigen. This helped to confirm that the same organism produced human leprosy and the infection in mice and that was the main cause of the lepromin reaction.
本文描述了两种使用酶消化法从感染小鼠组织中制备悬浮液的方法。将小鼠“麻风菌素”悬浮液与标准人麻风菌素作为皮肤试验抗原，用于49例不同类型麻风病患者。小鼠“麻风菌素”引发的反应与标准麻风菌素引发的反应非常相似，瘤型麻风患者对这两种抗原均无反应。这有助于证实人类麻风病和小鼠感染是由同一生物体引起的，并且麻风菌素反应的主要原因是[此处原文缺失关键信息]。
