Kaga A
Hokkaido Igaku Zasshi. 1979;54(2):147-61.
In a previous paper, we reported an inhibitory effect on growth rate and plasma lipid composition in rats of browning substances obtained from ethanol extraction of minced egg plant. In order to know active principle(s) in browning substances, attempts were made to condense the substances and chlorogenic acid was separated. The ingestion of chlorogenic acid and other browning substances such as dopameranin and catechin were examined for their biological activity. Active principle(s) in the browning substances appeared to interfere with digestion and utilization of dietic protein. The principle resided in dialyzable fraction in enzymatically produced materials and in nondialyzable fraction in materials obtained by chemical oxidation. Ingestion of nondialyzable fraction caused an elevation of total serum cholesterol level, but little change in serum fatty acid composition.
在之前的一篇论文中，我们报道了从切碎的茄子乙醇提取物中获得的褐色物质对大鼠生长速率和血浆脂质成分具有抑制作用。为了了解褐色物质中的活性成分，我们尝试对这些物质进行浓缩并分离出了绿原酸。研究了绿原酸以及其他褐色物质（如多巴黑素和儿茶素）的生物活性。褐色物质中的活性成分似乎会干扰膳食蛋白质的消化和利用。该成分存在于酶促反应产物的可透析部分以及化学氧化产物的不可透析部分中。摄入不可透析部分会导致血清总胆固醇水平升高，但血清脂肪酸组成变化不大。
