意大利人的红细胞乙二醛酶I多态性。一种变异表型的报告。

Red cell glyoxalase I polymorphism in Italians. Report of a variant phenotype.

作者信息

Ranzani G, Antonini G, Santachiara-Benerecetti A S

出版信息

Hum Hered. 1979;29(5):261-4. doi: 10.1159/000153055.

Abstract

The glyoxalase I polymorphism was studied in 1,490 unrelated subjects from three different areas of Italy (Milan, Rome and Naples). The following frequencies of GLO2 allele were observed: Milan 0.57, Rome 0.59, Naples 0.61, and a significant difference between Milan and Naples was found (p less than 0.02). An anomalous phenotype is also described which permits us to postulate a new allele producing an isozyme with low activity and electrophoretically slower than those corresponding to GLO1 and GLO2 alleles.

摘要

在来自意大利三个不同地区（米兰、罗马和那不勒斯）的1490名无亲缘关系的受试者中研究了乙二醛酶I多态性。观察到GLO2等位基因的以下频率：米兰为0.57，罗马为0.59，那不勒斯为0.61，并且发现米兰和那不勒斯之间存在显著差异（p小于0.02）。还描述了一种异常表型，这使我们能够推测存在一个新的等位基因，它产生一种同工酶，其活性较低且在电泳上比对应于GLO1和GLO2等位基因的同工酶慢。