Mue S, Sasaki T, Shibahara S, Takahashi M, Ohmi T, Yamauchi K, Suzuki S, Hida W, Takishima T
Int J Clin Pharmacol Biopharm. 1979 Aug;17(8):346-50.
Studies of metoprolol in asthmatic patients showed beta 1-selective blocking properties on the adrenergic receptor. Metoprolol in a dose of 40 mg given orally to 9 asthmatic patients significantly decreased the pulse rate at 60 and 120 minutes and the systolic blood pressure at 120 minutes but did not cause any increase of respiratory impedance, measured by the forced oscillation technique. A double-blind test was carried out to compare the effects of metoprolol and inactive placebo on the respiratory response to isoproterenol in 24 asthmatic patients. In the metoprolol group, systolic blood pressure decreased significantly and pulse rate at rest also tended to decrease. There was no significant difference between the metoprolol and placebo groups in the respiratory response to an isoproterenol aerosol.
对哮喘患者使用美托洛尔的研究显示，其对肾上腺素能受体具有β1选择性阻断特性。给9名哮喘患者口服40毫克剂量的美托洛尔，在60分钟和120分钟时显著降低了脉搏率，在120分钟时降低了收缩压，但通过强迫振荡技术测量，并未导致呼吸阻抗增加。进行了一项双盲试验，比较美托洛尔和无活性安慰剂对24名哮喘患者异丙肾上腺素呼吸反应的影响。在美托洛尔组中，收缩压显著降低，静息脉搏率也有下降趋势。美托洛尔组和安慰剂组对异丙肾上腺素气雾剂的呼吸反应没有显著差异。
