Rönning O, Kylämarkula S
J Anat. 1979 Jun;128(Pt 4):789-801.
In order to elucidate the reactions of neurocentral synchondroses to different forces, the first cervical vertebra of 10 or 25 days old rats was transplanted into sex-matched litter mates. Some vertebrae were transplanted as a whole, in some only the ventral part with its synchondroses was transplanted and, in others the lumen was furnished with an expanding sponge or a spring. The transplantation was done subcutaneously and, in the case of the fragments, intracerebrally as well. The synchondroses of the vertebrae transplanted at 10 days did not differ very much from those of the host 5, 10 or 15 days after the operation, whereas in the vertebrae transplanted at 25 days the synchondroses underwent synostosis earlier than in situ. The synchondroses of the transplanted fragments, and especially of those placed intracerebrally, remained open longer than those in the whole vertebral transplants; the sponge and and the spring also delayed closure. In the synchondroses transplanted at 25 days there was a strong reduction in alcian blue staining, whereas in the spring loaded synchondroses the stainability persisted longer, maybe as an adaptation to the tensile force. It seems that the inherent potential of the neurocentral synchondroses to obliterate at a certain time can be altered by changing the biomechanical conditions.
为了阐明神经中央软骨结合对不同力的反应，将10日龄或25日龄大鼠的第一颈椎移植到性别匹配的同窝仔鼠体内。一些椎体作为一个整体进行移植，一些仅移植其软骨结合的腹侧部分，还有一些则在椎管内植入膨胀海绵或弹簧。移植在皮下进行，对于碎片则也在脑内进行。10日龄时移植的椎体的软骨结合在术后5、10或15天与宿主的软骨结合差异不大，而25日龄时移植的椎体的软骨结合比原位软骨结合更早发生骨性融合。移植碎片的软骨结合，尤其是脑内植入碎片的软骨结合，比整个椎体移植的软骨结合开放时间更长；海绵和弹簧也延迟了闭合。在25日龄时移植的软骨结合中，阿尔新蓝染色明显减少，而在加载弹簧的软骨结合中，染色性持续时间更长，这可能是对张力的一种适应。似乎可以通过改变生物力学条件来改变神经中央软骨结合在特定时间闭塞的内在潜力。
