Becker D I, Toverud S U, Ontjes D A, Cooper C W
J Endocrinol Invest. 1979 Apr-Jun;2(2):159-64. doi: 10.1007/BF03349308.
As part of an initial study we have attempted to ascertain whether lactating women exhibit high, clearly measurable levels of immunoreactive calcitonin (CT). Plasma levels of CT were measured in women who had been lactating for either a short time (less than 4 months) or a very long time (17-73 months). In 2 of 18 women lactating for only a short time CT levels were high and easily measured (greater than 200 pg/ml) while, in contrast, CT levels were undetectable (less than 60 pg/ml) in all of 16 nonlactating control subjects. In all six of the women studied who had been lactating for a long time, measurable levels of CT were observed, although provocative testing of women with measurable plasma CT using iv pentagastrin and calcium did not show a consistent pattern of CT secretory response. Thus, out of the total of 24 lactating women studied, one third were found to have measurable plasma levels of CT. The findings agree with studies in experimental animals which have indicated hypercalcitoninemia during lactation, but the factors responsible for the elevated CT levels during lactation remain to be elucidated.
作为一项初步研究的一部分，我们试图确定哺乳期妇女是否表现出高且可明确测量的免疫反应性降钙素（CT）水平。对哺乳期较短（少于4个月）或非常长（17 - 73个月）的妇女测量了血浆CT水平。在18名哺乳期较短的妇女中，有2名的CT水平较高且易于测量（大于200 pg/ml），而相比之下，16名非哺乳期对照受试者的CT水平均检测不到（小于60 pg/ml）。在研究的所有6名哺乳期较长的妇女中，均观察到了可测量的CT水平，尽管使用静脉注射五肽胃泌素和钙对血浆CT可测量的妇女进行激发试验并未显示出一致的CT分泌反应模式。因此，在总共24名研究的哺乳期妇女中，发现三分之一的人血浆CT水平可测量。这些发现与实验动物研究一致，后者表明哺乳期存在高降钙素血症，但哺乳期CT水平升高的原因仍有待阐明。
