Boonnamsiri V, Kermode J C, Thompson B D
J Endocrinol. 1979 Aug;82(2):227-34. doi: 10.1677/joe.0.0820227.
Radio-iodide was administered by prolonged continuous intravenous infusion to rats maintained under iodine-replete conditions and in moderate iodine deficiency. A close approximation to equilibrium labelling was thereby achieved. Labelled iodocompounds extracted from various tissues were analysed by thin-layer chromatography. Moderate iodine deficiency resulted in a slight increase in the ratio of mono-iodotyrosine to di-iodotyrosine in the thyroid. No change in the ratio of tri-iodothyronine (T3) to thyroxine (T4) was found in thyroid, plasma or skeletal muscle. Faecal excretion of T3 declined appreciably relative to that of T4. Under iodine-replete conditions the ratio of thyroidal secretion rates of T3 and T4 was estimated to be more than three times higher than the ratio of these iodocompounds within the thyroid. Heterogeneity of thyroglobulin structure and function may explain these observations.
在碘充足和中度碘缺乏条件下饲养的大鼠，通过长时间持续静脉输注给予放射性碘化物，从而实现了接近平衡标记的状态。从各种组织中提取的标记碘化合物通过薄层色谱法进行分析。中度碘缺乏导致甲状腺中一碘酪氨酸与二碘酪氨酸的比例略有增加。在甲状腺、血浆或骨骼肌中，三碘甲状腺原氨酸（T3）与甲状腺素（T4）的比例未发现变化。相对于T4，T3的粪便排泄量明显下降。在碘充足的条件下，T3和T4的甲状腺分泌率之比估计比甲状腺内这些碘化合物的比例高三倍以上。甲状腺球蛋白结构和功能的异质性可能解释了这些观察结果。
