大鼠对日粮中长链奇数碳脂肪酸的胴体沉积及其在饥饿期间对血浆葡萄糖和酮体的影响。

Carcass deposition of dietary long-chain odd carbon fatty acids by rats and their effect on plasma glucose and ketone bodies during starvation.

作者信息

Anderson R L, Volpenhein R A

出版信息

J Nutr. 1979 Oct;109(10):1810-4. doi: 10.1093/jn/109.10.1810.

DOI:10.1093/jn/109.10.1810

Abstract

Weanling rats were fed diets containing various levels (0 to 40% of total dietary acids) of long chain, odd-carbon fatty acids (OCFA, 15:0 + 17:0) for 5 weeks. The OCFA did not significantly alter growth or feed efficiency and the OCFA were deposited in the carcass fat in proportion to their concentration in the diet fat. After the 5-week ingestion period, the rats were starved for 48 hours and the effect of carcass OCFA content on weight loss, fat loss, urinary total nitrogen, plasma glucose concentration and plasma ketone body concentrations was determined as a function of starvation time. The results demonstrate that OCFA catabolism during starvation results in a dose related increase in plasma glucose and dose related decrease in plasma ketone bodies without significantly altering the total weight loss, carcass fat loss, or urinary total nitrogen. Finally, the carcass percentage of OCFA did not change during starvation showing that these acids are as readily lost from the carcass during starvation as even chain fatty acids.

摘要

将断乳大鼠喂养含不同水平（占总膳食酸的0%至40%）长链奇数碳脂肪酸（OCFA，15:0 + 17:0）的日粮5周。OCFA未显著改变生长或饲料效率，且OCFA按其在日粮脂肪中的浓度比例沉积在胴体脂肪中。在5周的摄入期后，将大鼠饥饿48小时，并测定胴体OCFA含量对体重减轻、脂肪损失、尿总氮、血浆葡萄糖浓度和血浆酮体浓度的影响，作为饥饿时间的函数。结果表明，饥饿期间OCFA分解代谢导致血浆葡萄糖呈剂量相关增加，血浆酮体呈剂量相关减少，而总体重减轻、胴体脂肪损失或尿总氮无显著改变。最后，饥饿期间OCFA的胴体百分比未发生变化，表明这些酸在饥饿期间与偶数链脂肪酸一样容易从胴体中流失。