Bercu B B, Haupt R, Johnsonbaugh R, Rodbard D
J Pediatr. 1979 Nov;95(5 Pt 1):716-21. doi: 10.1016/s0022-3476(79)80717-9.
The interval between the onset of QRS of the electrocardiogram and the arrival of the pulse wave at the brachial artery, as detected by the appearance of Korotkoff sounds at diastolic pressure (QKd), provides a measure of a pulse wave arrival time, i.e., the sum of the pre-ejection period and a pulse transmission time. This measurement has proven useful in the evaluation of cardiovascular disease, thyroid and catecholamine status, and several other conditions in adults. In order to standardize this measurement in children, measurements were obtained on 63 normal children ranging in age from 7 months to 18 years. Because of the dependence of pulse transmission time on the distance of propagation, the QKd interval (in msec) is related to height (H in cm) by the equation: QKd = 56.6 + 0.797H. By use of this equation one can obtain a "height corrected QKd." Correction for pulse rate is not necessary for resting subjects. These normal ranges permit use of the QKd interval for clinical studies in children. These studies also permit measurement of the mean pulse wave velocity for a group of individuals. PWV (m/sec) increases with age according to the equation: PWV = 2.44 + 0.203 A, (A in years) with a correlation coefficient of r = 0.823. This implies progressive loss of functional elasticity of the major arteries throughout childhood.
心电图QRS波起始至肱动脉脉搏波到达（通过舒张压时柯氏音的出现来检测，即QKd）的时间间隔，可用于测量脉搏波传导时间，即射血前期与脉搏传播时间之和。这种测量方法已被证明在评估成人的心血管疾病、甲状腺和儿茶酚胺状态以及其他几种情况时很有用。为了使儿童的这种测量标准化，对63名年龄在7个月至18岁的正常儿童进行了测量。由于脉搏传播时间取决于传播距离，QKd间隔（以毫秒为单位）与身高（以厘米为单位的H）的关系方程为：QKd = 56.6 + 0.797H。通过使用这个方程，可以得到一个“身高校正后的QKd”。对于静息状态的受试者，无需对脉搏率进行校正。这些正常范围使得QKd间隔可用于儿童的临床研究。这些研究还允许测量一组个体的平均脉搏波速度。脉搏波速度（PWV，单位：米/秒）随年龄增长的方程为：PWV = 2.44 + 0.203A（A为年龄，单位：岁），相关系数r = 0.823。这意味着在整个儿童期，主要动脉的功能弹性逐渐丧失。
