Latour J G, Groulx C
J Pharmacol Exp Ther. 1979 Oct;211(1):171-3.
Several antiplatelet drugs (aspirin, sulfinpyrazone, hydroxychloroquine, dipyridamole, BL-3459, pyridinolcarbamate) were assayed for their ability to prevent the generalized Shwartzman reaction initiated by endotoxin in the pregnant rat, and compared to glucocorticoids (dexamethasone, hydrocortisone). The drugs were administered in a single large dose a few hours before provocation of the reaction. In opposition to glucocorticoids and beside BL-3459 which interfere with other mechanisms involved in the phenomenon, the tested inhibitors of platelet aggregation were found incapable of preventing or reducing the severity of the Shwartzman reaction.
对几种抗血小板药物（阿司匹林、磺吡酮、羟氯喹、双嘧达莫、BL - 3459、吡啶醇氨基甲酸酯）进行了检测，以评估它们预防内毒素引发的孕鼠全身性施瓦茨曼反应的能力，并与糖皮质激素（地塞米松、氢化可的松）进行比较。在引发反应前数小时给予单次大剂量药物。与糖皮质激素相反，除了干扰该现象中其他机制的BL - 3459外，所测试的血小板聚集抑制剂均无法预防或减轻施瓦茨曼反应的严重程度。
