呋喃妥因在实验性尿路感染中的作用部位。
Site of action of nitrofurantoin in experimental urinary tract infection.
作者信息
Rocha H, da Silva Teles E, Barros M
出版信息
Appl Microbiol. 1969 Oct;18(4):547-9. doi: 10.1128/am.18.4.547-549.1969.
The effectiveness of nitrofurantoin in suppressing bacterial growth in the urinary tract was evaluated by using two different experimental models. Pyelonephritis was produced in rats by direct inoculation of 10(4)Escherichia coli in the medulla of left kidney. Ascending urinary tract infection was induced by inoculation into the urinary bladder of 10(7)Proteus mirabilis, after a partial cystectomy. Nitrofurantoin was shown to be effective in suppressing bladder bacteriuria, in preventing ascending pyelonephritis, and also in preventing bacterial multiplication in kidney tissue following direct inoculation.
通过使用两种不同的实验模型评估了呋喃妥因在抑制尿路细菌生长方面的有效性。通过将10⁴ 大肠杆菌直接接种到左肾髓质中，在大鼠中诱发肾盂肾炎。在部分膀胱切除术后，通过向膀胱接种10⁷奇异变形杆菌诱发上行性尿路感染。结果表明，呋喃妥因在抑制膀胱菌尿、预防上行性肾盂肾炎以及预防直接接种后肾组织中的细菌繁殖方面均有效。
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