苯并-15-冠-5聚醚（抗球虫离子载体类似物）的合成

Synthesis of Benzo-15-crown-5 polyethers, anticoccidial ionophore analogues.

作者信息

Brown G R, Foubister A J

出版信息

J Med Chem. 1979 Aug;22(8):997-9. doi: 10.1021/jm00194a021.

Abstract

Synthesis of eight benzo-15-crown-5 derivatives I (R = H, CO2Me, CO2H, Me; R1 = H, CO2H, CO2Me, CHO, CH=CHCO2H, CH2CH2CO2H) designed as rigid cyclic analogues of the anticoccidial ionophores is described. No anticoccidial activity was observed in chickens, but moderate activity in tissue culture was found for I (R = Me, R1 = H; R = R1 = H) and dibenzo-18-crown-6.

摘要

本文描述了八种苯并-15-冠-5衍生物I（R = H、CO2Me、CO2H、Me；R1 = H、CO2H、CO2Me、CHO、CH=CHCO2H、CH2CH2CO2H）的合成，这些衍生物被设计为抗球虫离子载体的刚性环状类似物。在鸡身上未观察到抗球虫活性，但发现I（R = Me，R1 = H；R = R1 = H）和二苯并-18-冠-6在组织培养中有中等活性。