抗寄生虫药。3. 新型2-吡啶基-5-异硫氰酸酯苯并咪唑的合成及驱虫活性
Antiparasitic agents. 3. Synthesis and anthelmintic activities of novel 2-pyridinyl-5-isothiocyanatobenzimidazoles.
作者信息
Haugwitz R D, Maurer B V, Jacobs G A, Narayanan V L, Cruthers L, Szanto J
出版信息
J Med Chem. 1979 Sep;22(9):1113-8. doi: 10.1021/jm00195a021.
PMID:490558
Abstract
The preparation and anthelmintic activities of a series of 2-pyridinyl-5-isothiocyanatobenzimidazoles are described. In the primary oral mouse screen, six derivatives showed 100% taeniacidal activity at 0.2% in diet. The most active member in this series, 1c, is potentially an effective gastrointestinal nematocide in sheep at 50 mg/kg po.
摘要
描述了一系列2-吡啶基-5-异硫氰酸酯基苯并咪唑的制备及其驱虫活性。在初次口服小鼠筛选中，六种衍生物在日粮中浓度为0.2%时显示出100%的杀绦虫活性。该系列中活性最高的成员1c，经口服给予绵羊50mg/kg时，可能是一种有效的胃肠线虫杀虫剂。
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