咪唑并[4,5-f]喹啉。4. 一系列咪唑并[4,5-f]喹啉-9-醇的合成及驱虫活性
Imidazo[4,5-f]quinolines. 4. Synthesis and anthelmintic activity of a series of imidazo[4,5-f]quinolin-9-ols.
作者信息
Alaimo R J, Spencer C F, Sheffer J B, Storrin R J, Hatton C J, Kohls R E
出版信息
J Med Chem. 1978 Mar;21(3):298-300. doi: 10.1021/jm00201a014.
PMID:564407
Abstract
A series of 2-arylimidazo[4,5-f]quinolin-9-ols has been prepared by a multistep procedure from various 5-aminobenzimidazoles. These compounds possess a significant degree of anthelmintic activity against the mouse tapeworm Hymenolepis nana. The most active compound is the 2-(2-furyl) analogue. Additional anthelmintic testing is reported for this compound.
摘要
通过多步程序从各种5-氨基苯并咪唑制备了一系列2-芳基咪唑并[4,5-f]喹啉-9-醇。这些化合物对小鼠绦虫微小膜壳绦虫具有显著程度的驱虫活性。活性最高的化合物是2-(2-呋喃基)类似物。报道了对该化合物的额外驱虫测试。
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